Unverified
Steadier afternoons
Kept a note on my phone so I wouldn't invent a memory later. After 5 weeks, The 3pm wall got shorter. I didn't change the rest of the week much. Scale was flat. That wasn't why I ran it.
Mitochondrial Research
MOTS-c
Mitochondrial-Derived Peptide
20 mg / Lyophilized powder
Pricing pendingPrice for this size is coming soon. Ordering will open once pricing is confirmed.
Brand vial shown. Refer to the product details for compound and quantity.
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region. Research has focused on its role in metabolic homeostasis, skeletal muscle signaling, insulin sensitivity, and age-associated mitochondrial stress responses. It is studied as a signaling peptide that links mitochondrial status with nuclear and cellular metabolic programs.
Molecular Formula
C101H152N28O22S2
Molecular Weight
2174.6 g/mol
Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Example report / Inventory batch pending
Lumira / MOTS-c / 10mg sample
99.2%
Reported sample purity · HPLC
See the science.
Read the report.
Third-party analysis by Pacific Coast Biologics.
Report issued July 19, 2026.
Research Areas
- Mitochondrial signaling
- Metabolic homeostasis
- Insulin sensitivity pathways
- Skeletal muscle metabolism
- Age-associated stress response
Mechanism of Action
MOTS-c is studied for AMPK-linked metabolic signaling and stress-response pathways that may coordinate mitochondrial and nuclear communication. Research suggests it can influence glucose utilization, lipid handling, and skeletal muscle metabolic adaptation without acting as an androgenic hormone.
Storage & Handling
Storage
Store lyophilized powder at -20°C. Once reconstituted, store at 2-8°C and use within 21 days.
Reconstitution
Reconstitute with bacteriostatic water. Add solvent slowly along the vial wall. Do not shake — gently swirl until fully dissolved.
From the community
Customer reviews.
Feedback on MOTS-c.
Customer accounts are anecdotal and do not establish safety or efficacy. Products are for laboratory research use only.
- Unverified
Slow burn
Using it around training, not instead of it. Easy cardio stopped feeling like a negotiation. Took about 6 weeks before I trusted the note. No stimulant feeling, which mattered.
- Unverified
Better on cardio days
I log sleep and sessions, so this isn't a vibe check. Protocol was simple, same window most days, 8 weeks. The thing I actually noticed: Fasted walks were less grim. Strength numbers didn't jump. What changed was how often I canceled the hard part of the day. Paired with a walk after dinner and that combo did more than either alone. Would run it again next block.
- Unverified
Less of a crash
Kept a note on my phone so I wouldn't invent a memory later. After 3 weeks, Sessions felt more repeatable, not easier. I didn't change the rest of the week much. No stimulant feeling, which mattered.
- Unverified
Not a stimulant
Kept a note on my phone so I wouldn't invent a memory later. After 6 weeks, The random flat days thinned out around week three. I didn't change the rest of the week much. Watch HRV ticked up a little. Could be noise.
- Unverified
Week three
Skeptical of anything that gets talked about this much. Gave it a clean 10 weeks without stacking three other new things. I actually hit the step goal without bargaining — that's the part I'd repeat. Could still be coincidence. I'm writing down what I noticed, not a mechanism. Paired with a walk after dinner and that combo did more than either alone. Would run it again next block.
A closer reading
The scientific review.
One selected primary paper, with its findings and limits. A starting point for reading, not a complete assessment of the evidence.
A mitochondrial peptide and metabolic regulation
Cell experiments & mouse models
What the researchers observed
The study identified MOTS-c and linked its cellular activity to AMPK signaling. Treated mice showed changes in insulin sensitivity and diet-related metabolic outcomes.
What this does not establish
Mouse treatment outcomes and cellular mechanisms do not demonstrate therapeutic benefit from MOTS-c administration in humans.
Lee C et al. · Cell Metabolism · 2015
Read the primary paper PMID 25738459Research Use Only: This product is sold for laboratory and research purposes only. It is not intended for human consumption and is not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you agree to use this product solely for legitimate research purposes.