Corticosteroid-impairment of healing and gastric pentadecapeptide BPC-157 creams in burned mice.
Sikiric P, Seiwerth S, Mise S et al. · Burns : journal of the International Society for Burn Injuries · PMID 12781609
Study summary
Main finding
The authors reported improved microscopic and mechanical healing measures with BPC-157 cream, including in corticosteroid-exposed animals. Gastric lesions and splenic-cell responses were also examined.
Burned mice receiving corticosteroids and topical creams
How the study was set up
Burned mice were studied with and without corticosteroid exposure, using experimental BPC-157 cream and control groups over 21 days.
What the researchers measured
Skin strength, microscopic healing, gastric injury, and splenic immune-cell responses were examined.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
The paper addresses wound healing within a particular burn-and-steroid model. It cannot establish reversal of steroid-related healing problems in patients.
What this does not establish
Mouse burns, a topical preparation, and concurrent corticosteroids are a specific experimental setting. Findings do not establish clinical burn care or effects through other routes.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article · Research Support, Non-U.S. Gov't