Antiinflammatory effect of BPC 157 on experimental periodontitis in rats.
Keremi B, Lohinai Z, Komora P et al. · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · PMID 20388954
Study summary
Main finding
Treatment reduced measured inflammation, plasma extravasation, and alveolar bone loss in the experimental model.
Researchers induced periodontitis around a rat molar with a ligature and examined the tissue after the experimental period.
What the researchers measured
Gum blood flow, fluid leakage, inflammatory tissue changes, and bone loss using micro-CT were measured.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
Inflammation and bone-loss findings differed from controls, but blood flow in healthy gums did not change. The paper does not establish treatment of human gum disease.
What this does not establish
An induced rodent periodontal lesion is not a clinical trial of human gum disease.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article · Research Support, Non-U.S. Gov't