Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing.
Brcic L, Brcic I, Staresinic M et al. · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · PMID 20388964
Study summary
Main finding
The authors reported altered angiogenesis and VEGF-associated markers during rat muscle and tendon healing. They did not observe a direct angiogenic effect in the tested cell cultures.
Researchers compared cell cultures with rat models of crushed muscle and surgically divided muscle or tendon.
What the researchers measured
Blood-vessel markers (CD34 and factor VIII) and VEGF, a protein involved in vessel growth, were examined during tissue healing.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
Vessel-related changes occurred in injured rat tissue, while the cultures showed no direct vessel-growth effect. The result depended on the model and should not be described as a universal angiogenic effect.
What this does not establish
Different outcomes in culture and animals underline the importance of model context. These experiments do not establish human injury recovery.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.