The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.
Chang CH, Tsai WC, Lin MS et al. · Journal of applied physiology (Bethesda, Md. : 1985) · PMID 21030672
Study summary
Main finding
Researchers observed greater tendon-cell outgrowth, migration, and survival under stress. Direct cell proliferation was not increased in the tested cultures.
Rat Achilles tendon explants and cultured tendon fibroblasts were studied with and without BPC-157. Fibroblasts are cells that help produce connective tissue.
What the researchers measured
Cell outgrowth from tendon tissue, movement and spreading of cells, proliferation, and survival during hydrogen-peroxide stress. The researchers also examined proteins involved in cell movement.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
The observed changes concerned cell movement and survival. Direct proliferation did not increase in the tested cultures, so more outgrowth should not be read as proof that BPC-157 simply makes tendon cells multiply.
What this does not establish
Isolated rat tissue and cell behavior do not establish injury recovery or safety in people.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article · Research Support, Non-U.S. Gov't