Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation.
Hsieh MJ, Liu HT, Wang CN et al. · Journal of molecular medicine (Berlin, Germany) · PMID 27847966
Study summary
Main finding
The study linked vessel formation and rat blood-flow recovery to VEGFR2 expression and signaling. Endothelial-cell experiments investigated receptor internalization and the Akt-eNOS pathway.
Endothelial cells, chick membranes & rat limb ischemia
How the study was set up
The study combined chick membrane and endothelial-cell assays with a rat model of restricted hind-limb blood flow.
What the researchers measured
Vessel density, cell tube formation, laser-measured blood flow, and VEGFR2/Akt/eNOS signaling were assessed. An inhibitor tested the role of receptor internalization.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
The experiments connected vascular measurements with a possible signaling pathway. Improved blood flow in a rat injury model does not establish circulation or healing benefits in people.
What this does not establish
Cultured human cells remain preclinical evidence. These models do not establish clinical benefit or validate a commercial research preparation.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article · Research Support, Non-U.S. Gov't