Isolated rat aortic rings and vascular cells were studied with endothelial removal and inhibitors of nitric-oxide and signaling pathways.
What the researchers measured
Vessel relaxation, nitric-oxide production, and Src/Caveolin-1/eNOS pathway changes were measured.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
Relaxation was largely dependent on the vessel's endothelial lining and nitric oxide under the tested conditions, with slight residual relaxation at the highest concentration after the lining was removed. This isolated-tissue mechanism does not establish blood-pressure or cardiovascular outcomes in people.
What this does not establish
Isolated vessels and cells do not establish cardiovascular benefit or safety in people.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article · Research Support, Non-U.S. Gov't
Indexed subjects
Animals · Aorta, Thoracic · Caveolin 1 · Endothelial Cells · Enzyme Activation · In Vitro Techniques · Male · NG-Nitroarginine Methyl Ester · Nitric Oxide · Nitric Oxide Synthase Type III · Peptide Fragments · Proteins · Rats · Rats, Sprague-Dawley · Signal Transduction · Vasodilation · src-Family Kinases
Source checked
October 4, 2026. Years follow journal issues; online-first dates may differ.