Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction.
Qin Q, Delrio S, Wan J et al. · International journal of cardiology · PMID 29242099
Study summary
Main finding
Lower endogenous MOTS-c was associated with endothelial dysfunction in the clinical sample; experimental vessel responses improved in rodent preparations.
Angina patient observations and rodent aortic-ring assays
How the study was set up
Forty patients undergoing coronary testing were grouped by endothelial function; separate experiments used rodent aortic rings.
What the researchers measured
Naturally occurring blood MOTS-c levels and coronary responses were compared. Isolated vessels were tested for relaxation responses.
How to read this evidence
This paper combines observations in people with laboratory or animal experiments. Measuring a naturally occurring peptide in people is different from testing peptide administration.
Results in context
Lower human peptide levels were associated with poorer endothelial function. Vessel pretreatment altered rodent responses, but no human administration benefit was tested.
What this does not establish
Endogenous levels and isolated-vessel assays do not establish that administering MOTS-c improves human vascular disease.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article · Research Support, Non-U.S. Gov't