Mice with surgically removed ovaries were used to model hormone-related metabolic changes, with AMPK-blocking comparisons.
What the researchers measured
Body weight, insulin sensitivity, brown-fat activation, white-fat inflammation, and lipid metabolism were assessed.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
The model explores effects following abrupt surgical hormone loss. It is not a clinical trial in menopausal women.
What this does not establish
This is an animal model, not a trial of MOTS-c in postmenopausal people.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article · Research Support, Non-U.S. Gov't