Human genetic cohorts and mouse variant experiments
How the study was set up
A genetic association analysis across three cohorts totaling 27,527 people was paired with cell and mouse comparisons of MOTS-c and its K14Q variant.
What the researchers measured
Diabetes prevalence, activity-related associations, glucose tolerance, weight, and insulin-related cell responses were assessed.
How to read this evidence
This paper combines observations in people with laboratory or animal experiments. Measuring a naturally occurring peptide in people is different from testing peptide administration.
Results in context
Associations differed by sex and physical activity. A naturally occurring variant and animal experiments do not establish that administered MOTS-c prevents human diabetes.
What this does not establish
Genetic associations can depend on population, sex, and behavior and are not evidence from a human administration trial.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article · Research Support, Non-U.S. Gov't
Indexed subjects
3T3-L1 Cells · Adult · Aged · Aged, 80 and over · Animals · DNA, Mitochondrial · Diabetes Mellitus, Type 2 · Female · Genetic Predisposition to Disease · Glucose · Humans · Insulin · Insulin Resistance · Male · Mice · Middle Aged · Mitochondrial Proteins · Polymorphism, Single Nucleotide · Proto-Oncogene Proteins c-akt
Source checked
October 4, 2026. Years follow journal issues; online-first dates may differ.