Human plasma observations, mouse muscle, and cultured myotubes
How the study was set up
The paper combined human blood-level associations with cultured mouse muscle cells and diet-induced obese mice.
What the researchers measured
MOTS-c and myostatin levels, muscle-cell atrophy, and CK2/PTEN/mTORC2/Akt/FOXO1 signaling were assessed.
How to read this evidence
This paper combines observations in people with laboratory or animal experiments. Measuring a naturally occurring peptide in people is different from testing peptide administration.
Results in context
The human component measured naturally occurring levels; administration experiments were in cells and mice. Their combination does not establish treatment of muscle wasting in people.
What this does not establish
The human component was observational. Experimental administration in mice and cells does not establish prevention of muscle loss in people.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article · Research Support, N.I.H., Extramural · Research Support, Non-U.S. Gov't
Indexed subjects
Adult · Aged · Aged, 80 and over · Animals · Cells, Cultured · Diet, High-Fat · Humans · Male · Mice · Mice, Inbred C57BL · Middle Aged · Mitochondrial Proteins · Muscle, Skeletal · Muscular Atrophy · Myostatin · Palmitic Acid · Signal Transduction · Young Adult
Source checked
October 4, 2026. Years follow journal issues; online-first dates may differ.