Male mice were randomized to non-immobilized control, cast-immobilized control, or cast immobilization with MOTS-c for eight days.
What the researchers measured
Muscle mass, inflammatory markers, Akt/FOXO signaling, gene expression, and muscle lipid and collagen were measured.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
Muscle loss was attenuated rather than eliminated. This short preventive mouse experiment does not establish rehabilitation outcomes after human immobilization.
What this does not establish
Short-term experimental immobilization does not establish human rehabilitation outcomes or long-term safety.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.