[Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats].
Mendzheritskiĭ AM, Karantysh GV, Ivonina KO · Advances in gerontology = Uspekhi gerontologii · PMID 21809624
Study summary
Main finding
This comparison of Pinealon and Cortexin reported survival and behavioral changes after arterial occlusion. Pinealon was associated with reduced exploratory and motor behavior and a moderate rise in caspase-3 activity.
Older rats received Pinealon or Cortexin before experimental carotid-artery occlusion, with sham-operated comparisons.
What the researchers measured
Survival, behavioral activity, movement, motivation-related responses, and brain caspase-3 activity were assessed.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
The reported behavior included reduced activity as well as other changes. Pretreatment and enzyme measurements do not establish cognitive improvement after stroke in people.
What this does not establish
The original paper is in Russian, with an English abstract. Animal pretreatment findings and mixed behavioral effects do not establish clinical stroke recovery or cognitive benefit.
Publication & source
Why this paper is included
Pinealon pretreatment was tested in an old-rat cerebral-ischemia and caspase experiment.