Pinealon protects the rat offspring from prenatal hyperhomocysteinemia.
Arutjunyan A, Kozina L, Stvolinskiy S et al. · International journal of clinical and experimental medicine · PMID 22567179
Study summary
Main finding
In a prenatal hyperhomocysteinemia model, researchers reported changes in offspring learning measures and oxidative-stress resistance of isolated neurons.
Pregnant rats received a methionine-enriched diet to create a prenatal high-homocysteine model. Researchers examined offspring after Pinealon exposure in that experimental setting.
What the researchers measured
Offspring spatial learning and orientation, and oxidative-stress responses in neurons isolated from the cerebellum. The cell work measured reactive oxygen accumulation and necrotic cell death.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
Behavioral observations and isolated-neuron measurements were reported in offspring exposed to a particular prenatal stress model. These findings do not describe cognition in healthy adult humans or show that a change in a cell-stress marker predicts a clinical benefit.
What this does not establish
A specific prenatal rat model cannot establish cognitive benefits in healthy adults or clinical neurological outcomes.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article
Source checked
October 4, 2026. Years follow journal issues; online-first dates may differ.