[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].
Mendzheritskiĭ AM, Karantysh GV, Ryzhak GA et al. · Advances in gerontology = Uspekhi gerontologii · PMID 25051764
Study summary
Main finding
Treatment altered cytokine and caspase-related measures that the authors discussed in relation to neurogenesis.
Older rats exposed to acute hypoxia were studied with Pinealon or Cortexin.
What the researchers measured
Brain caspase-3 activity and blood IL-6 and tumor-necrosis-factor markers were measured.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
The authors interpreted these markers as possible neurogenesis and inflammation-related changes. Marker changes alone do not directly measure restored cognition or clinical neurological benefit.
What this does not establish
Marker changes do not directly demonstrate formation of new functional neurons or clinical cognitive benefit.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.