[Effect of peptide geroprotectors on the navigation system learning and caspase-3 in brain structures in rats of different age].

Study summary

Main finding

Researchers reported improved learning measures and region-specific caspase changes after peptide exposure.

What was studied: Young and older rats in a Morris water maze
How the study was set up: Young and older rats were studied with Pinealon and Cortexin during learning experiments.
What the researchers measured: Water-maze learning and regional brain caspase-3 activity and content were assessed.
How to read this evidence: Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.

Results in context

Learning differences were reported in rats, while the link with caspase-3 remained an interpretation. The paper does not measure human memory or aging.

What this does not establish

Maze performance in rats does not establish treatment of human cognitive impairment.

Publication & source

Why this paper is included: The rat learning and caspase experiment directly tested Pinealon.
Publication indexing: English Abstract · Journal Article
Source checked: October 4, 2026. Years follow journal issues; online-first dates may differ.

Open PubMed record PMID 28976148 · Journal and full-text links

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