Semaglutide, tirzepatide, and retatrutide attenuate the interoceptive effects of alcohol in male and female rats.
Windram M, Lovelock DF, Carew JM et al. · Psychopharmacology · PMID 40699363
Study summary
Main finding
Acute retatrutide, tirzepatide, and semaglutide reduced alcohol discrimination. Repeated-treatment findings in this paper concerned semaglutide rather than retatrutide.
Male and female rats in operant alcohol-discrimination experiments
How the study was set up
Male and female rats were trained to distinguish alcohol's internal effects in an operant task; acute retatrutide was compared with other incretin agonists.
What the researchers measured
Alcohol discrimination was measured. Repeated-treatment and withdrawal experiments in this paper used semaglutide.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
Retatrutide altered an experimental alcohol cue. That result does not establish reduced drinking or treatment of alcohol-use disorder in people, and the repeated semaglutide findings should not be assigned to retatrutide.
What this does not establish
A rat discrimination task does not establish reduced drinking or treatment of alcohol use disorder in humans. The three drugs should not be treated as interchangeable.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.