Post hoc analyses of two phase 2 trials and cultured human hepatocytes
How the study was set up
Post-hoc analyses of two phase 2 trials were combined with experiments in cultured human liver cells.
What the researchers measured
Circulating ANGPTL proteins and complexes, blood lipids, their correlations, and receptor-dependent secretion in liver cultures were assessed.
How to read this evidence
This analysis uses participants from an existing trial to examine another question. It adds information, but is not a separate trial or independent replication.
Results in context
Protein and lipid changes occurred together, while cell experiments suggested a glucagon-receptor mechanism. The clinical correlations do not alone prove that this mechanism caused the lipid changes.
What this does not establish
These are secondary analyses of existing trials, not additional independent trials. Associations and cell experiments cannot prove clinical cardiovascular benefit.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.