Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.
Anisimov VN, Khavinson VK, Provinciali M et al. · International journal of cancer · PMID 12209581
Study summary
Main finding
Epitalon reduced cumulative mammary tumor counts and maximum tumor size in this model. Lung metastasis size decreased, but the number of metastases did not.
Female HER-2/neu transgenic mice were compared after Epitalon, Vilon, or saline exposure.
What the researchers measured
Mammary tumor number and size, lung metastases, and HER-2/neu gene expression were measured.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
Different peptides had different outcomes, and metastasis size changed without a reduced metastasis count. Findings from this tumor-prone strain do not establish human anticancer benefit.
What this does not establish
One genetically tumor-prone mouse model cannot establish human cancer prevention, treatment, or long-term safety. Findings differ by endpoint.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.