75 compound-focused publications · 15 studies with detailed explanations.
Click a paper title or Read summary to open its reading page. Find a detailed explanation or a short, attributed abstract excerpt, then follow the original source for the full conclusion.
75 of 75 publications · Showing 1–30
Zhang Y, Qian S, Yang Q et al. · Cell death & disease
Why included: The lymphoma-cell research experimentally tested Epitalon in senescence and drug-resistance mechanisms.
Journal Article
Al-Dulaimi S, Thomas R, Matta S et al. · Biogerontology
Why included: The compound is a named subject of the publication title.
Published Erratum · No abstract indexed
Al-Dulaimi S, Thomas R, Matta S et al. · Biogerontology
Why included: The compound is a named subject of the publication title.
A published correction is linked in the original PubMed record.
Journal Article · Research Support, Non-U.S. Gov't
Gatta M, Dovizio M, Milillo C et al. · Stem cell reviews and reports
Why included: The compound is a named subject of the publication title.
Journal Article · Research Support, Non-U.S. Gov't
Araj SK, Brzezik J, Mądra-Gackowska K et al. · International journal of molecular sciences
Why included: The compound is a named subject of the publication title.
Journal Article · Review
Ullah S, Haider Z, Perera CD et al. · Life sciences
Why included: The compound is a named subject of the publication title.
Journal Article
Lezhava T, Jokhadze T, Monaselidze J et al. · Georgian medical news
Why included: Lymphocyte experiments from older donors tested Epitalon (AEDG) and chromatin measures.
Journal Article
Yue X, Liu SL, Guo JN et al. · Aging
Why included: The compound is a named subject of the publication title.
Journal Article · Research Support, Non-U.S. Gov't
Avolio F, Martinotti S, Khavinson VK et al. · International journal of molecular sciences
Why included: The THP-1 cell study directly tested Epitalon among five short peptides.
Journal Article
Ivko OM, Drobintseva AO, Leont'eva DO et al. · Advances in gerontology = Uspekhi gerontologii
Why included: The human pineal-cell culture study tested AEDG (Epitalon) and senescence markers.
Journal Article
Khavinson V, Diomede F, Mironova E et al. · Molecules (Basel, Switzerland)
Why included: The compound is a named subject of the publication title.
Journal Article
Vanhee C, Moens G, Van Hoeck E et al. · Drug testing and analysis
Why included: This analytical letter concerns identification of Epitalon in two pharmaceutical preparations; it does not test the therapeutic claims in its title, and PubMed provides no abstract.
Letter · Research Support, Non-U.S. Gov't · No abstract indexed
Korenevsky AV, Milyutina YP, Bukalyov AV et al. · Advances in gerontology = Uspekhi gerontologii
Why included: The compound is a named subject of the publication title.
English Abstract · Journal Article
Dzhokhadze TA, Buadze TZh, Rubanov KD et al. · Georgian medical news
Why included: The laboratory study tested Epitalon effects on functional genome measures in samples from tuberculosis patients.
English Abstract · Journal Article
Arutjunyan A, Kozina L, Milyutina Y et al. · Current aging science
Why included: The rat reproductive-system experiment compared Epitalon and Epithalamine; the preparations are distinct.
Journal Article · Research Support, Non-U.S. Gov't
Khavinson VKh, Linkova NS, Kvetnoy IM et al. · Bulletin of experimental biology and medicine
Why included: A rat pinealocyte experiment directly tested Epitalon and melatonin-related measures.
Journal Article
Linkova NS, Khavinson VKh, Chalisova NI et al. · Bulletin of experimental biology and medicine
Why included: Pineal-cell experiments directly tested Epithalon in immune-progenitor differentiation.
Journal Article
Fedoreyeva LI, Kireev II, Khavinson VKh et al. · Biochemistry. Biokhimiia
Why included: The study tested HeLa-cell uptake of fluorescently labeled Epithalon and separate in vitro peptide-DNA interactions.
Journal Article · Research Support, Non-U.S. Gov't
Vinogradova IA · Advances in gerontology = Uspekhi gerontologii
Why included: The compound is a named subject of the publication title.
English Abstract · Journal Article
Uzenbaeva LB, Vinogradova IA, Golubeva AG et al. · Advances in gerontology = Uspekhi gerontologii
Why included: The compound is a named subject of the publication title.
English Abstract · Journal Article
Il'ina TN, Vinogradova IA, Iliukha VA et al. · Advances in gerontology = Uspekhi gerontologii
Why included: A rat experiment tested Epitalon against liver antioxidant measures under different lighting conditions.
Journal Article
Kuznik BI, Pateiuk AV, Baranchugova LM et al. · Advances in gerontology = Uspekhi gerontologii
Why included: The compound is a named subject of the publication title.
English Abstract · Journal Article
Vinogradova IA, Bukalev AV, Zabezhinski MA et al. · Bulletin of experimental biology and medicine
Why included: A male-rat aging experiment tested Ala-Glu-Asp-Gly, explicitly identified as Epithalone, under different lighting regimens.
Evaluation Study · Journal Article · Research Support, Non-U.S. Gov't
Dzhokhadze TA, Ganozishvili MN, Lezhava TA · Georgian medical news
Why included: The chromosome study directly tested Epithalon exposure and fragile-site measures.
English Abstract · Journal Article
Kozina LS, Arutiunian AV, Stvolinskiĭ SL et al. · Advances in gerontology = Uspekhi gerontologii
Why included: Cell and lipoprotein oxidation experiments directly tested Epitalon alongside other peptides.
English Abstract · Journal Article
Kozina LS · Advances in gerontology = Uspekhi gerontologii
Why included: Hypoxia experiments directly compared Epitalon with other peptide interventions.
Journal Article
Barabanova SV, Artyukhina ZE, Ovchinnikova KT et al. · Neuroscience and behavioral physiology
Why included: The rat hypothalamus experiment tested Epitalon and Vilon in c-Fos/interleukin-2 measures.
Journal Article · Research Support, Non-U.S. Gov't
Vinogradova IA, Bukalev AV, Zabezhinski MA et al. · Bulletin of experimental biology and medicine
Why included: A female-rat lifespan and tumor experiment tested Ala-Glu-Asp-Gly, explicitly identified as Epithalon.
Journal Article · Research Support, Non-U.S. Gov't
Miliutina IuP, Kozina LS, Arutiunian AV et al. · Advances in gerontology = Uspekhi gerontologii
Why included: Rat preoptic-hypothalamus organ cultures directly tested Epitalon.
English Abstract · Journal Article
Labunets' IF · Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)
Why included: A mouse bone-marrow study compared Epithalon with Epithalamin; these are distinct preparations.
English Abstract · Journal Article
A published correction is linked in the original PubMed record.
Normal and cancer cells did not show the same dominant pathway: telomerase-related changes were reported in normal cells, while ALT activity was prominent in cancer cells. Telomere extension across these models should not be presented as a uniform beneficial or safe outcome.
These are cell-line experiments, not a human longevity trial. Results in cancer cells require separate interpretation and do not establish safety or reversal of aging.
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Al-Dulaimi S et al. · Biogerontology · 2025
Why included: The compound is a named subject of the publication title.
Read the original study PMID 40908429 · PubMedOpen study summaryChanges occurred in cultured cells, rather than patients with diabetic retinopathy. The paper does not demonstrate restored vision or clinical retinal healing.
Human-derived cells are not a clinical retinopathy trial; ocular delivery, efficacy, and safety remain unestablished by this experiment.
The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
Gatta M et al. · Stem cell reviews and reports · 2025
Why included: The compound is a named subject of the publication title.
Read the original study PMID 40493162 · PubMedOpen study summaryIncreased hormone production in cells does not demonstrate improved sleep, circadian health, or melatonin regulation in people.
Cultured pineal cells do not establish improved sleep or circadian outcomes in people.
Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture.
Khavinson VKh et al. · Bulletin of experimental biology and medicine · 2012
Why included: A rat pinealocyte experiment directly tested Epitalon and melatonin-related measures.
Read the original study PMID 22816096 · PubMedOpen study summaryMean lifespan was largely unchanged, despite changes in some mortality-pattern and tumor measures. A change in a population aging parameter is not equivalent to increased average lifespan.
The unchanged mean lifespan and lighting-dependent model limit broad longevity claims; these results are not human evidence.
Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens.
Vinogradova IA et al. · Bulletin of experimental biology and medicine · 2008
Why included: A male-rat aging experiment tested Ala-Glu-Asp-Gly, explicitly identified as Epithalone, under different lighting regimens.
Read the original study PMID 19110597 · PubMedOpen study summaryLifespan did not change under the standard day/night regimen; some late-survival outcomes changed under other lighting conditions. The environmental dependence limits broad longevity conclusions.
Benefits were conditional on the model and lighting environment, rather than a general demonstration of lifespan extension.
Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.
Vinogradova IA et al. · Bulletin of experimental biology and medicine · 2007
Why included: A female-rat lifespan and tumor experiment tested Ala-Glu-Asp-Gly, explicitly identified as Epithalon.
Read the original study PMID 18856211 · PubMedOpen study summaryLonger proliferation in a culture is a cellular outcome. It does not measure human lifespan, healthspan, or the safety of extending cell division.
Extending cell division in culture does not establish healthy aging, longer human lifespan, or clinical safety.
Peptide promotes overcoming of the division limit in human somatic cell.
Khavinson VKh et al. · Bulletin of experimental biology and medicine · 2004
Why included: A cultured human fetal-fibroblast experiment tested Epitalon and cell-division/telomere measures.
Read the original study PMID 15455129 · PubMedOpen study summaryThe measured outcomes concern chromosome maintenance in cultured cells. A longer telomere in that setting is not a measurement of a person's lifespan, healthspan, or biological age, and cannot establish an anti-aging benefit in people.
Human cells in a dish are not a human trial. These observations do not establish longer life or reversal of aging in people.
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.
Khavinson VK et al. · Bulletin of Experimental Biology and Medicine · 2003
Why included: The compound is a named subject of the publication title.
Read the original study PMID 12937682 · PubMedOpen study summaryMean lifespan did not change, although some late-survival measures increased. Total tumor incidence also did not change; these distinctions matter more than a general anti-aging claim.
Selected tail-of-survival outcomes should not be read as an increase in average lifespan. Results from one female mouse strain do not establish human longevity or long-term safety.
Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.
Anisimov VN et al. · Biogerontology · 2003
Why included: The compound is a named subject of the publication title.
Read the original study PMID 14501183 · PubMedOpen study summaryEffects differed with the timing of exposure. This carcinogen model measures tissue changes, not prevention or treatment of human colon cancer.
A carcinogen-induced rat model does not establish human cancer prevention or treatment.
Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa.
Kossoy G et al. · International journal of molecular medicine · 2003
Why included: The compound is a named subject of the publication title.
Read the original study PMID 12964022 · PubMedOpen study summaryThe model and exposure timing are specific to inherited rodent retinal disease. The findings do not establish treatment of human vision loss.
A particular rat retinal model and exposure schedule do not establish prevention of human eye disease.
Retinoprotective effect of Epithalon in campbell rats of various ages.
Khavinson VKh et al. · Bulletin of experimental biology and medicine · 2003
Why included: The compound is a named subject of the publication title.
Read the original study PMID 12910293 · PubMedOpen study summaryThe findings concern a specific cancer-prone mouse strain. They do not establish cancer prevention or lifespan extension in people.
A tumor-prone transgenic mouse model does not establish human longevity or cancer prevention.
Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice.
Anisimov VN et al. · Bulletin of experimental biology and medicine · 2002
Why included: The compound is a named subject of the publication title.
Read the original study PMID 12459848 · PubMedOpen study summaryThe paper describes stress-related signaling and cell responses. These are different from clinical measures of immune protection or stress resilience.
Experimental immune signaling is not evidence of a safe or beneficial immune treatment in people.
Effect of epitalon on interleukin-1beta signal transduction and the reaction of thymocyte blast transformation under stress.
Khavinson VKh et al. · Neuro endocrinology letters · 2002
Why included: The compound is a named subject of the publication title.
Read the original study PMID 12500162 · PubMedOpen study summaryDifferent peptides had different outcomes, and metastasis size changed without a reduced metastasis count. Findings from this tumor-prone strain do not establish human anticancer benefit.
One genetically tumor-prone mouse model cannot establish human cancer prevention, treatment, or long-term safety. Findings differ by endpoint.
Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.
Anisimov VN et al. · International journal of cancer · 2002
Why included: The compound is a named subject of the publication title.
Read the original study PMID 12209581 · PubMedOpen study summaryThe report concerns hormone rhythms in nonhuman primates. It does not establish improved sleep or anti-aging outcomes in people.
A nonhuman primate hormone study does not establish human sleep improvement or longevity.
Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys.
Khavinson V et al. · Neuro endocrinology letters · 2001
Why included: The compound is a named subject of the publication title.
Read the original study PMID 11524632 · PubMedOpen study summaryThis is another report on primate hormone rhythms. Publication counts do not establish independent replication or clinical sleep and longevity benefits.
The short abstract provides limited methodological detail. Hormone rhythms in monkeys do not establish improved human sleep, longevity, or clinical benefit.
Regulatory effect of Epithalon on production of melatonin and cortisol in old monkeys.
Goncharova ND et al. · Bulletin of experimental biology and medicine · 2001
Why included: The compound is a named subject of the publication title.
Read the original study PMID 11550036 · PubMedOpen study summary