Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa.

Study summary

Main finding

Continuous treatment reduced tumor-cell mitotic activity and increased apoptosis, with effects depending on treatment timing.

What was studied: Chemically induced colon tumors in rats
How the study was set up: Eighty male rats exposed to a colon carcinogen were divided into groups receiving Epitalon during different stages of tumor development or saline.
What the researchers measured: Tumor-cell division, programmed cell death, tissue stroma, and lymphoid infiltration around and within tumors were assessed.
How to read this evidence: Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.

Effects differed with the timing of exposure. This carcinogen model measures tissue changes, not prevention or treatment of human colon cancer.

A carcinogen-induced rat model does not establish human cancer prevention or treatment.

Why this paper is included: The compound is a named subject of the publication title.
Publication indexing: Journal Article · Research Support, Non-U.S. Gov't
Indexed subjects: 1,2-Dimethylhydrazine · Animals · Apoptosis · Carcinogens · Cell Division · Colonic Neoplasms · In Situ Nick-End Labeling · Lymphatic Metastasis · Male · Mitosis · Mucous Membrane · Oligopeptides · Peptides · Rats
Source checked: October 4, 2026. Years follow journal issues; online-first dates may differ.

Educational research information. A publication does not verify the identity, quality, or safety of products sold here.

Study summary

Continuous treatment reduced tumor-cell mitotic activity and increased apoptosis, with effects depending on treatment timing.

What was studied: Chemically induced colon tumors in rats
How the study was set up: Eighty male rats exposed to a colon carcinogen were divided into groups receiving Epitalon during different stages of tumor development or saline.
What the researchers measured: Tumor-cell division, programmed cell death, tissue stroma, and lymphoid infiltration around and within tumors were assessed.
How to read this evidence: Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.

Effects differed with the timing of exposure. This carcinogen model measures tissue changes, not prevention or treatment of human colon cancer.

A carcinogen-induced rat model does not establish human cancer prevention or treatment.

Why this paper is included: The compound is a named subject of the publication title.
Publication indexing: Journal Article · Research Support, Non-U.S. Gov't
Indexed subjects: 1,2-Dimethylhydrazine · Animals · Apoptosis · Carcinogens · Cell Division · Colonic Neoplasms · In Situ Nick-End Labeling · Lymphatic Metastasis · Male · Mitosis · Mucous Membrane · Oligopeptides · Peptides · Rats
Source checked: October 4, 2026. Years follow journal issues; online-first dates may differ.

Educational research information. A publication does not verify the identity, quality, or safety of products sold here.