Effects of glycyl-histidyl-lysyl chelated Cu(II) on ferritin dependent lipid peroxidation.
Miller DM, DeSilva D, Pickart L et al. · Advances in experimental medicine and biology · PMID 2244543
Study summary
Main finding
GHK-Cu inhibited lipid oxidation when ferritin was the iron source and reduced ferritin iron release. Significant superoxide-dismutase-like or ceruloplasmin-like activity was not observed.
Laboratory ferritin iron-release and lipid-peroxidation assays
How the study was set up
Biochemical experiments examined iron-driven lipid oxidation and ferritin iron release in the presence of GHK-Cu.
What the researchers measured
Lipid peroxidation, iron release, and selected antioxidant-enzyme-like activities were measured.
How to read this evidence
This paper examines laboratory measurements or analytical methods. It is not a study of treatment outcomes in people.
Results in context
Inhibition depended on ferritin being the iron source; broad antioxidant activities were not demonstrated. The proposed wound-related mechanism was not a clinical wound-healing test.
What this does not establish
A biochemical mechanism proposed from laboratory assays does not establish clinical wound healing or general antioxidant effects in people.
Publication & source
Why this paper is included
A biochemical ferritin/lipid-oxidation experiment tested glycyl-histidyl-lysyl-chelated copper.