Tripeptide-copper complex GHK-Cu (II) transiently improved healing outcome in a rat model of ACL reconstruction.
Fu SC, Cheuk YC, Chiu WY et al. · Journal of orthopaedic research : official publication of the Orthopaedic Research Society · PMID 25731775
Study summary
Main finding
Selected knee-laxity and graft-stiffness measures improved at six weeks, but benefits were not maintained at twelve weeks; several other outcomes did not differ.
Seventy-two rats undergoing ACL reconstruction were randomized to saline or GHK-Cu groups, with assessments at six and 12 weeks.
What the researchers measured
Knee laxity, graft stiffness and failure load, gait, and tissue scores were measured.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
Some six-week mechanical outcomes improved, but later differences and several other outcomes were not significant. The results do not establish lasting graft benefit or human recovery.
What this does not establish
Temporary, endpoint-specific effects in rats do not establish durable human ligament repair.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article · Research Support, Non-U.S. Gov't