GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis.
Wang X, Liu B, Xu Q et al. · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · PMID 28370978
Study summary
Main finding
Liposomal GHK-Cu promoted cell proliferation and angiogenesis and shortened healing time in the tested mouse wounds.
Endothelial cell cultures and scald wounds in mice
How the study was set up
GHK-Cu encapsulated in liposomes was tested in endothelial-cell cultures and a mouse scald-wound model, including comparisons with free peptide.
What the researchers measured
Cell growth and cell-cycle proteins, growth-factor signals, vessel-related markers, and wound-healing time were assessed.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
Delivery formulation affected the findings. Results with an experimental liposome cannot be assumed for free peptide or commercial skin products.
What this does not establish
A specific liposomal formulation and animal burns do not establish equivalent effects from other products or human wound care.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.