DSS-induced colitis in mice and mouse-cell co-cultures
How the study was set up
A chemically induced mouse colitis model was combined with macrophage and intestinal-cell co-cultures and gene-silencing experiments.
What the researchers measured
Weight, disease-activity scores, colon damage, mucus cells, barrier proteins, inflammatory markers, and SIRT1/STAT3 signaling were assessed.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
Multiple outcomes changed in these experimental models, with more than one possible inflammatory pathway. The paper does not establish treatment of human ulcerative colitis.
What this does not establish
Chemically induced mouse colitis and cultured mouse cells do not establish treatment of human inflammatory bowel disease or route-specific safety.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article
Source checked
October 4, 2026. Years follow journal issues; online-first dates may differ.