Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction.
Wessells H, Gralnek D, Dorr R et al. · Urology · PMID 11018622
Study summary
Main finding
Melanotan II produced more reported erectile responses and higher sexual-desire scores than placebo. Nausea and yawning/stretching were more frequent, including episodes of severe nausea.
Ten men with erectile dysfunction and organic risk factors entered a blinded, placebo-controlled crossover experiment.
What the researchers measured
Erection duration and rigidity were monitored over six hours, with questionnaires on desire and adverse effects.
How to read this evidence
The paper includes research in people. Its comparison groups, participant selection, follow-up, and measured outcomes determine how far the findings can be applied. The label alone does not establish efficacy or safety.
Results in context
Short-term responses were reported, but nausea was also frequent and sometimes severe. The small laboratory experiment does not describe long-term outcomes.
What this does not establish
This was a small, short-term experiment in a selected clinical population. It does not establish chronic-use safety, tanning safety, or the quality of retail products.
Publication & source
Why this paper is included
A crossover study administered melanotan II to men with erectile dysfunction and organic risk factors.
Publication indexing
Clinical Trial · Journal Article · Randomized Controlled Trial · Research Support, Non-U.S. Gov't · Research Support, U.S. Gov't, P.H.S.