Mice with selected receptor or mast-cell deficiencies were compared with controls, alongside mast-cell experiments.
What the researchers measured
Body temperature, circulating histamine, and responses to histamine-receptor blockade were measured.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
The transient cooling response depended on mast cells and histamine signaling in these mice. It does not establish the same response or mechanism in people.
What this does not establish
Mouse mechanisms do not establish the frequency or severity of temperature changes in people.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article · Research Support, N.I.H., Extramural · Research Support, N.I.H., Intramural