Melanotan II, a melanocortin agonist, partially rescues the impaired thermogenic capacity of pituitary adenylate cyclase-activating polypeptide deficient mice.
McMillan TR, Forster MAM, Short LI et al. · Experimental physiology · PMID 33332767
Study summary
Main finding
Melanotan II partly restored thermogenic responses and altered adipose lipid use in the deficient mice.
Female mice with or without PACAP deficiency were studied during three weeks of cold acclimation.
What the researchers measured
Stimulated metabolic rate, lipid use, and fat-tissue remodeling were assessed.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
Melanotan II partly restored impaired heat-production responses in a genetic model. The study concerns cold-response physiology rather than clinical weight loss.
What this does not establish
A genetically deficient mouse model does not establish metabolic effects or safety in the general human population.
Publication & source
Why this paper is included
The compound is a named subject of the publication title.
Publication indexing
Journal Article · Research Support, Non-U.S. Gov't