Full-thickness rat wounds treated with full-length thymosin beta4 were compared with saline-treated wounds. A separate cell assay examined movement of keratinocytes, which are cells of the skin's outer layer.
What the researchers measured
New epithelial coverage of the wound, wound contraction, collagen deposition, blood-vessel formation, and keratinocyte migration.
How to read this evidence
Researchers studied cells, isolated tissue, or animals. These experiments can help explain a mechanism, but do not establish benefits or safety in people. Human cells grown in a laboratory also belong in this category.
Results in context
The paper combined tissue-level wound observations with a cell-movement experiment. It studied thymosin beta4, so its results cannot be assigned to a product called TB-500 without establishing the preparation's sequence and formulation.
What this does not establish
This is related-compound evidence. The name TB-500 does not establish equivalence to the thymosin beta4 preparation used in this paper; sequence and formulation must be checked.
This collection includes related thymosin beta4 research. Parent or engineered peptide findings do not establish that a TB-500 fragment or a product sold under that name has the same effects.
Publication & source
Why this paper is included
The title focuses on thymosin beta4 or TB-500; parent-peptide findings do not establish TB-500 fragment effects.
Publication indexing
Journal Article · Research Support, U.S. Gov't, Non-P.H.S.
Indexed subjects
Animals · Cell Movement · Cells, Cultured · Dose-Response Relationship, Drug · Keratinocytes · Mice · Mice, Inbred BALB C · Thymosin · Wound Healing · Thymosin beta(4)
Source checked
October 4, 2026. Years follow journal issues; online-first dates may differ.